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Title: Effects of Egg Ingestion on Endothelial Function in Adults with Coronary Artery Disease: A Randomized, Controlled, Crossover Trial
Topic: Cardiovascular Health / Endothelial Function*
Funding Source: Egg Nutrition Center
Funding Period: 2010-2011
Study Design: Randomized Single-Blind Controlled Crossover Trial

Eggs contain dietary cholesterol, but are an excellent source of high quality protein and micronutrients and are low in total fat and saturated fat. Our prior studies have shown no adverse effects of 6 weeks of daily egg ingestion on endothelial function (a measure of cardiac risk) in healthy adults, or in adults at risk for heart disease. Our new study will examine the health effects of eggs in people with coronary heart disease. Although restricting dietary cholesterol is routinely recommended for patients with coronary disease, there has been a lack of consistent evidence that dietary cholesterol has an effect on serum cholesterol levels.

Further Study Details:

The study will examine the effects of 6 weeks of daily intake of 2 eggs (containing twice the amount of dietary cholesterol currently recommended for heart disease patients), compared to egg substitute and a typical high carbohydrate breakfast, on endothelial function or serum lipids (cholesterol, triglycerides, HLD, LDL, or VLDL) in adults with coronary heart disease.


The study is expected to be completed by mid-2012. Findings will be available in late 2012.

  1. Men older than 35 years;
  2. post-menopausal women not currently on hormone replacement therapy;
  3. non-smokers;
  4. coronary artery disease as defined by the presence of at least one coronary artery stenosis >50% determined angiographically or through a documented history of myocardial infarction.

Eggs are an inexpensive source of protein and other nutrients, but also contain cholesterol.

Our prior studies have shown that eating eggs every day for a few weeks does not increase blood cholesterol levels of healthy adults or adults with high cholesterol or triglycerides. We now want to see if this holds true for people with Coronary Heart Disease.

If you qualify for this study, there will be three periods when you will be assigned to eat eggs, Egg Beaters, or a high-carbohydrate meal for breakfast. You will also complete food diaries and surveys, and will come to our center for medical tests (blood work, blood pressure, and an ultrasound on your arm).

  • Be a man over 35 years or a post-menopausal woman
  • Have Coronary Heart Disease diagnosed by a physician or have had heart attack in the past
  • Be a non-smoker
  • Receive medical test results
  • Free breakfast foods during the study period
  • Get paid $300
Application: Apply now!

Changed at: 6/1/2016 8:11 AM Changed by: Lisa Seaberg
Created at: 1/18/2011 11:25 AM Created by: Judy Treu